Vermandel M., Quidet M., Vignion-Dewalle A. S., Leroy H. A., Leroux B., Mordon S., Reyns N.   Comparison of different treatment schemes in 5-ALA interstitial photodynamic therapy for high-grade glioma in a preclinical model: An MRI study.  Photodiagnosis Photodyn Ther.  2018

BACKGROUND: There is currently no therapy that prevents high-grade glioma recurrence. Thus, these primary brain tumors have unfavorable outcomes. Recently, 5-ALA photodynamic therapy (PDT) has been proposed to delay relapse and is highly expected to have potential synergistic effects with the current standard of care. However, PDT treatment delivery needs to be optimized by evaluating the impact of both the number of fractions and the light power used. OBJECTIVES: Previous studies have reported MRI examination-based outcomes for PDT in glioblastoma. Our study aimed to compare MRI markers across different treatment schemes that use interstitial PDT in high-grade glioma in a preclinical model. MATERIALS AND METHODS: Forty-eight "nude" rats were grafted with human U87 cells into the right putamen and subsequently submitted to interstitial PDT. The rats were randomized into six groups, including two different sham groups and four different treated groups (5 fractions at 5 mW or 30 mW and 2 fractions at 5 mW or 30 mW). After photosensitizer (PS) precursor (5-ALA) intake, an optical fiber was introduced into the tumor. Treatment effects were assessed with early high-field MRI to acquire T1 and T2 diffusion and perfusion images. RESULTS: There was no difference in the variation of the diffusion coefficient among the six groups (p = 0.0549, Kruskal-Wallis test). However, a significant difference was identified among the six groups in terms of variation in perfusion (p = 0.048, Kruskal-Wallis test), supporting a lesional effect in the treated groups. Additionally, the sham groups had significantly smaller edema volumes than were observed in the treated groups. Moreover, the 5-fraction group treated with 30 mW was associated with edema volumes that were significantly greater than those in the 5-fraction group treated with 5 mW (p = 0.019). CONCLUSION: Based on observations of MRI data and considering treatment effects, the 5-fraction group treated at 5 mW was not significantly different from the other treated groups in terms of cell deaths, characterized by diffusion imaging, or necrosis level. However, the significantly lower level of edema observed in this group indicated that this treatment scheme had limited toxicity.

Vermandel M., Dupont C., Lecomte F., Deleporte P., Mordon S. R., Reyns N.   INDYGO: FOLLOW-UP AND PRELIMINARY RESULTS OF THE FIRST EVER PILOT CLINICAL TRIAL ON INTRAOPERATIVE 5-ALA PDT FOR THE TREATMENT OF NEWLY DIAGNOSED GLIOBLASTOMA.  Lasers Surg. Med..  2018 ;50 :S46-S46
Saddiki N., Hennion S., Viard R., Ramdane N., Lopes R., Baroncini M., Szurhaj W., Reyns N., Pruvo J. P., Delmaire C.   Encoding and immediate retrieval tasks in patients with epilepsy: a functional MRI study of verbal and visual memory.  J Neuroradiol.  2018 ;45 :157-163

PURPOSE: Medial lobe temporal structures and more specifically the hippocampus play a decisive role in episodic memory. Most of the memory functional magnetic resonance imaging (fMRI) studies evaluate the encoding phase; the retrieval phase being performed outside the MRI. We aimed to determine the ability to reveal greater hippocampal fMRI activations during retrieval phase. MATERIALS AND METHODS: Thirty-five epileptic patients underwent a two-step memory fMRI. During encoding phase, subjects were requested to identify the feminine or masculine gender of faces and words presented, in order to encourage stimulus encoding. One hour after, during retrieval phase, subjects had to recognize the word and face. We used an event-related design to identify hippocampal activations. RESULTS: There was no significant difference between patients with left temporal lobe epilepsy, patients with right temporal lobe epilepsy and patients with extratemporal lobe epilepsy on verbal and visual learning task. For words, patients demonstrated significantly more bilateral hippocampal activation for retrieval task than encoding task and when the tasks were associated than during encoding alone. Significant difference was seen between face-encoding alone and face retrieval alone. CONCLUSIONS: This study demonstrates the essential contribution of the retrieval task during a fMRI memory task but the number of patients with hippocampal activations was greater when the two tasks were taken into account.

Rouvière O., Puech P., Renard-Penna R., Claudon M., Roy C., Mège-Lechevallier F., Decaussin-Petrucci M., Dubreuil-Chambardel M., Magaud L., Remontet L., Ruffion A., Colombel M., Crouzet S., Schott A. M., Lemaitre L., Rabilloud M., Grenier N.   Use of prostate systematic and targeted biopsy on the basis of multiparametric MRI in biopsy-naive patients (MRI-FIRST): a prospective, multicentre, paired diagnostic study.  Lancet Oncol..  2018 ;20 :100-109
Gold M. H., Mordon S. R.   TREATMENT OF ACNE SCARRING WITH A NOVEL DUAL-WAVELENGTH LASER.  Lasers Surg. Med..  2018 ;50 :S22-S22
Fritel X., Collinet P., Revel-Delhom C., Canis M.   [CNGOF-HAS Endometriosis guidelines: Aim, method, organisation and limits].  Gynecol Obstet Fertil Senol.  2018 ;46 :139-143
Forestier A., Buob D., Mirault T., Puech P., Gnemmi V., Launay D., Hachulla E., Hatron P. Y., Lambert M.   No specific imaging pattern can help differentiate IgG4-related disease from idiopathic retroperitoneal fibrosis: 18 histologically proven cases.  Clin. Exp. Rheumatol..  2018
Fauconnier A., Borghese B., Huchon C., Thomassin-Naggara I., Philip C. A., Gauthier T., Bourdel N., Denouel A., Torre A., Collinet P., Canis M., Fritel X.   [Epidemiology and diagnosis strategy: CNGOF-HAS Endometriosis Guidelines].  Gynecol Obstet Fertil Senol.  2018 ;46 :223-230

Based on the best evidence available, we have provided guidelines for clinical practice to target the nature of endometriosis as a disease, the consequences of its natural history on management, and the clinical and imaging evaluation of the disease according to the level of care (primary care, specialized or referral). The frequency of endometriosis is unknown in the general population; endometriosis requires management when it causes symptoms (pain, infertility) or when it affect the function of an organ. In the absence of symptom, there is no need for follow-up or screening of the disease. Endometriosis may be responsible for various pain symptoms such as severe dysmenorrhea, deep dyspareunia, painful bowel movements or low urinary tract signs increasing with menstruation, or infertility. A careful evaluation of the symptoms and their impact on the quality of life should be made. The first-line examinations for the diagnosis of endometriosis are: digital examination and pelvic ultrasound. The second-line examinations are: the pelvic exam by an expert clinician, the pelvic MRI and/or the transvaginal ultrasound by an expert. MRI and ultrasound carrying different and complementary information. Other examinations may be considered as part of the pre-therapeutic assessment of the disease in case of specialized care. Diagnostic laparoscopy may be suggested in case of clinical suspicion of endometriosis whereas preoperative examinations have not proved the disease, it must be part of a management plan of endometriosis-related pain or infertility. During management, it is recommended to give comprehensive information on the different therapeutic alternatives, the benefits and risks expected from each treatment, the risk of recurrence, fertility, especially before surgery. The information must be personalized and take into account the expectations and preferences of the patient, and accompanied by an information notice given to the patient.

Farre C., Azahaf M., Nachury M., Branche J., Gerard R., Wils P., Desreumaux P., Ernst O., Pariente B.   Correlation between the Lemann Index and the Inflammatory Bowel Disease-Disability Index in Crohn''''s disease.  J. Crohns Colitis.  2018 ;12 :S193-S193
Dupont C., Vermandel M., Reyns N., Mordon S.   [Photodynamic therapy for the treatment of glioblastoma in neurosurgery].  Med Sci (Paris).  2018 ;34 :901-903